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Benign obesity a myth, even if blood pressure, cholesterol 'healthy,' study says

Dr. Caroline Kramer, an endocrinologist at Mount Sinai Hospital in Toronto, is shown in a handout photo. In an analysis of data pooled from several previous studies, researchers at Mount Sinai Hospital found people who were obese but metabolically healthy had a significantly increased risk of having a heart attack or stroke and of dying prematurely.
Image Credit: THE CANADIAN PRESS/HO, Vancouver police
December 03, 2013 - 5:00 AM

TORONTO - The notion that someone can be obese yet still healthy is a myth, say researchers, who found that obesity carries a higher risk of premature death compared to that of normal-weight people, regardless of cholesterol, blood pressure and blood-sugar readings.

In an analysis of data pooled from several previous studies, researchers at Toronto's Mount Sinai Hospital found people who were obese but metabolically healthy had a significantly increased risk of having a heart attack or stroke and of dying prematurely.

"Our research findings challenge the myth that there is such a thing as healthy obesity if people maintain normal-range readings of cholesterol, blood glucose and blood pressure," said endocrinologist Dr. Ravi Retnakaran, co-author of the study in this week's Annals of Internal Medicine.

Researchers reviewed eight studies from the last decade, which included a total of more than 61,000 participants who were followed for a mean period of 11 years.

The studies evaluated subjects' metabolic status, including cholesterol levels, blood-sugar levels and blood pressure. Measurements also included waist circumference, as excess abdominal fat tissue can contribute to the development of diabetes, for example.

The studies compared fatal and non-fatal cardiovascular events such as heart attack and stroke, as well as other causes of death like cancer, across three weight categories — normal, overweight and obese.

Researchers said the comparative risks for premature death in the three weight groups became especially apparent after 10 years of followup.

Lead author Dr. Catherine Kramer said that even in the absence of such markers as high blood pressure or elevated cholesterol, an obese person with a body mass index, or BMI, of 30 or greater had a 24 per cent greater risk of having a heart attack or stroke or of early death compared to a normal-weight person.

"So we are telling people and doctors that it is not OK to be obese, even though you don't have metabolic abnormalities," Kramer said in an interview Monday. "This excess of weight still confers increased risk for cardiovascular events."

For study participants who were overweight, with a body mass index of less than 30 but greater than 25, the risk of cardiovascular events was the same as for normal-weight subjects during the study periods.

"But we also evaluated all metabolic parameters — lipids, blood sugar, blood pressure — and we show that people with metabolically healthy overweight already have increases (in levels) compared to normal weight," said Kramer.

While those readings weren't yet in the so-called unhealthy zone, "this is a sign for us. Maybe they are still healthy now, but in five, 10 years, maybe (the excess weight) will have an effect on metabolic health."

Regardless of lab test results that point to a healthy metabolic profile, doctors need to stress to overweight and obese patients that they are potentially shortening their lives and strongly encourage them to shed excess pounds through diet and exercise, she said.

"Our message to physicians is that for obese individuals, normal metabolic status regarding blood pressure, cholesterol and blood glucose is not protective. If they can start to lose weight, that's a benefit."

Obesity raises the risk of developing a number of disorders, including cardiovascular disease, diabetes, some cancers, osteoarthritis and sleep apnea.

In 2011, about 18 per cent of Canadian adults were classified as obese.

News from © The Canadian Press, 2013
The Canadian Press

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