New AIDS treatment? Experimental drug blocks HIV from killing immune system cells in lab test - InfoNews

Current Conditions

Cloudy
-1.4°C

New AIDS treatment? Experimental drug blocks HIV from killing immune system cells in lab test

December 19, 2013 - 1:02 PM

NEW YORK, N.Y. - Can an experimental drug developed to treat epilepsy block the AIDS virus? A preliminary lab study suggests it's possible, and researchers are eager to try it in people.

Scientists experimented with the drug after uncovering details of how they believe HIV cripples the immune system to bring on AIDS.

When tested in human tissues in the laboratory, the drug "works beautifully" to prevent HIV from destroying key cells of the immune system, said Dr. Warner Greene of the Gladstone Institutes in San Francisco. Those results appear in a paper by Greene and others published online Thursday by the journal Nature.

In that work, and a companion study published in Science, Greene and colleagues focus on how HIV kills vital CD4 cells of the disease-fighting immune system.

Researchers have long known it infects some CD4 cells and turns them into virus-producing factories, killing them in the process. But far more cells die without undergoing that transformation. What is going on in these "bystander"CD4 cells?

The new work provides evidence that HIV enters these cells but fails to produce a full-blown infection, and in response the cells trigger a lethal attack on themselves by the immune system.

It's "more of a suicide than a murder," Greene said. "I believe this is the major mechanism through which CD4 cells are depleted, which is the hallmark of AIDS."

The epilepsy drug, which is not on the market, blocks an enzyme that the research identified as playing a key role in that immune system attack.

Prior studies of the drug in people show it is safe, Greene said. So the researchers are talking to the drug company about testing it in people infected with HIV. No timeline for such studies has been set, he said.

Greene said if such studies are successful, the drug might be used in people whose HIV resists standard drugs. It might also be useful as a temporary treatment to keep HIV at bay for people who can't immediately get standard drugs, he said. It's even possible, he speculated, that the enzyme-blocking drug might help scientists eradicate the virus from the body.

It's not clear yet whether the enzyme-blocking approach will produce a practical therapy for HIV-infected people, said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, who was not involved in the work.

But the new research behind that strategy is "an important advance" toward understanding how HIV kills immune system cells, he said.

__

Online:

Science: http://www.sciencemag.org

Nature: http://www.nature.com/nature

___

Malcolm Ritter can be followed at http://www.twitter.com/malcolmritter

News from © The Associated Press, 2013
The Associated Press

  • Popular kelowna News
  • Comments
  • Pier 1 closing all of its stores in Canada
    Pier 1 Imports, Inc. announced today that it has entered into bankruptcy protection and is pursuing a sale. The retailer  commenced voluntary Chapter 11 proceedings in the U.S. Bankrupt
  • Vernon's Atlantis waterpark gets a new name
    A popular Vernon waterpark is starting its transformation with a new name. Formerly known as Atlantis Waterslides, the waterpark, located north of the city along Highway 97, has been renamed
  • Killing of 7-year-old girl stokes anger in Mexico
    MEXICO CITY - The killing of a 7-year-old girl on the southern outskirts of Mexico City has stoked rising anger over brutal slayings of women, including one found stabbed to death and skinned earl
  • Mammoth's tooth found in Williams Lake and preserved for decades by B.C. family
    What was once part of a mammoth-sized smile now is a very old conversation starter in Bryan Johnson's Vancouver home. Johnson's stepfather found a mammoth tooth in a creek at the sou
  • Vernon family captures mesmerizing melting ice
    A Vernon family was on their way home from Kelowna when they made a pit stop after noticing a beautiful scene along Wood Lake. Matthew Royal and his daughters noticed how “cool”
View Site in: Desktop | Mobile